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Alcohol phramacotherapy > Drug Addiction Pharmacoth > Mental Health Pharmacothe >  



Pharmacotherapy, in conjunction with psychosocial interventions, is emerging as a valuable tool for alcohol dependence treatment. Currently, four pharmaceutical treatments are approved by the Food and Drug Administration for this purpose: Disulfiram, Acamprosate, oral Naltrexone, and the once-monthly injectable, extended-release Naltrexone. All four agents have demonstrated some ability to reduce drinking and/or increase time spent abstinent, but results have not always been consistent. Effective pharmacotherapies for alcohol dependence are thought to work by blocking the rewards of alcohol or stabilizing systems dysregulated by chronic alcohol intake, except Disulfiram, which has an aversive mechanism of action. 


SAMHSA TIP #49 Disulfiram chapter


SAMHSA TIP #49 Acamprosate chapter


Oral Naltrexone


Extended-Release Injectable Naltrexone